CHEMICAL AND BIOLOGICAL PROFILES OF TUSSILAGO FARFARA: STRUCTURES, NITRIC OXIDE INHIBITORY ACTIVITIES, AND INTERACTIONS WITH INOS PROTEIN

Chemical and biological profiles of Tussilago farfara: Structures, nitric oxide inhibitory activities, and interactions with iNOS protein

Tussilago farfara L.is a well-known herb plant and used widely in China, North Africa, and Europe.A phytochemical investigation to obtain new NO inhibitors resulted in the isolation of three new sesquiterpenes, one new phenolic diamond painting strand en zee derivative, and ten known compounds from the flower buds of T.farfara.Their structures were

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Golgi localization of SARS-CoV-2 spike protein and interaction with furin in cerebral COVID-19 microangiopathy: a clue to the central nervous system involvement?

In a neuropathological series of 20 COVID-19 cases, we analyzed six cases (three biopsies and three autopsies) with multiple foci predominantly affecting the white matter as shown by MRI.The cases presented with microhemorrhages evocative of small artery diseases.This COVID-19 associated cerebral microangiopathy (CCM) was characterized by perivascu

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